Body's Solution for Sleep

Hormone of Darkness

Deep inside the brain sits the tiny, pinecone-shaped pineal gland. As nighttime sets in, this pea-sized gland begins to produce and secrete the hormone of darkness: melatonin.

Melatonin participates in the regulation of the circadian rhythm and is associated with a soporific effect, hence promoting falling asleep.

It works by signaling to your body that it’s time for sleep, turning off day functions and switching on night functions. As melatonin levels rise, typically a few hours before bedtime, levels of cortisol, the stress hormone, fall. Breathing slows, body temperature falls, and soon your eyelids feel heavy.1

MELATONIN LEVELS BY TIME OF DAY


Physiological Melatonin Production Decline Can Undermine Sleep Health

Unfortunately, like many hormones, melatonin production declines significantly as we age.

Natural melatonin production peaks in puberty, and by age 30, levels have already dropped by more than half.1

Our modern lifestyle also has a negative impact. Late bedtime routines and exposure to blue light at dawn and nighttime both impact the natural circadian cycle and reduce melatonin secretion signaling.2

PHYSIOLOGICAL MELATONIN PRODUCTION DECLINES RAPIDLY WITH AGE, DECREASING ABILITY TO SLEEP

References:
  1. Minich DM, Henning M, Darley C, Fahoum M, Schuler CB, Frame J. Is Melatonin the "Next Vitamin D"?: A Review of Emerging Science, Clinical Uses, Safety, and Dietary Supplements. Nutrients. 2022 Sep 22;14(19):3934.
  2. Filling in the Gap of Sleep Disorders_Preliminary QL Phase Cross Country Report for Menarini by IPSOS_July 2023. (data on file).